Key result
Novel catheter-based coronary arteriography successfully visualizes coronary anatomy and proximal aorta in dogs.
Why the study?
A method was needed to demonstrate coronary arteries roentgenologically in dogs with intact chests using minimal contrast and a specialized catheter.
Catheter-based coronary imaging succeeds in intact dogs without ECG changes; leaves open safe human translation.
A method is described whereby the coronary arteries of dogs with intact chests can be regularly demonstrated roentgenologically by the use of small amounts of Diodrast injected through a specially devised catheter which is passed to the aortic sinus through a peripheral artery. The artery is preserved by suture. Electrocardiograms taken during the procedure were normal. The aortic valves of two excised hearts previously subjected to forceful trauma by the catheter, showed no abnormality. Characteristic arteriograms are reproduced, showing coronary arteries, separate cusps of the aortic valves, and the proximal aorta.
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PEARL et al. (1950) studied Intact dogs (animal model). Coronary arteriography using Diodrast injected through a specially devised catheter was evaluated on Demonstration of coronary arteries roentgenologically. Coronary arteriography using a specially devised catheter and Diodrast injection successfully demonstrated coronary arteries, aortic valve cusps, and proximal aorta in intact dogs.
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