What is the clinical evidence from this study?

Study design: Cohort. Population: Heart failure (n=414). Intervention: Anemia vs. No anemia. Primary outcome: 1-year all-cause mortality (p=0.041).

What does this research mean for the field?

Anemia is associated with significantly increased 1-year all-cause mortality in heart failure patients, driven by increased risk in HFpEF rather than HFrEF. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 30, 2020IJC Heart & VasculatureOpen Access

Relationship of anemia and clinical outcome in heart failure patients with preserved versus reduced ejection fraction in a rural area of Thailand

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Key result

Anemia linked to ~64% higher 1-year mortality in heart failure, particularly in HFpEF.

P=0.041
n=414

Why the study?

Limited data exists on the effects of anemia on heart failure outcomes in populations from developing countries with high anemia prevalence.

Population

414 heart failure patients hospitalized at Buriram Hospital in Thailand

Comparison

Anemia versus non-anemia groups

Design

Retrospective observational study

Follow-up

1 year

Authors

KCKittayaporn Chairat WRWipharak RattanavipanonMahidol University KTKrittika Tanyasaensook

Discussion

Member takes

Implication

Anemia may flag higher-risk HFpEF patients; leaves open whether correction improves survival in prospective trials.

Study Design

Type

Cohort (n=414)

Multicenter

PICO

Population

414 adult patients hospitalized with heart failure in a rural Thai hospital, followed for 1 year to evaluate the impact of anemia on mortality.

Exposure / Comparator

Anemia vs No anemia

Primary Outcome

1-year all-cause mortality, p=0.041

Main Result

Absolute Event Rate: 20.08% vs 12.26%

p-value: p=0.041

Limitations

Data were obtained from a single hospital, limiting generalizability.
The study population had a larger ratio of HFpEF than HFrEF, potentially skewing results.
Exclusion of about 50% of admitted HF patients due to the country's referral system.
Unable to perform a thorough analysis on the causes of anemia due to incomplete laboratory work-ups.
Did not analyze the impact of changes in hemoglobin levels over time.
Observational design leaves results susceptible to residual confounding factors.

Cite This Study

Chairat et al. (2020) conducted a cohort in Heart failure (n=414). Anemia vs. No anemia was evaluated on 1-year all-cause mortality (p=0.041). Anemia was associated with a significantly higher 1-year all-cause mortality rate compared to no anemia in patients with heart failure (20.08% vs 12.26%), with the risk being particularly elevated in the HFpEF subgroup (adjusted HR 2.667).

synapsesocial.com/papers/6ac482888a4dee4d202046e2 https://doi.org/10.1016/j.ijcha.2020.100597

Topics

Heart failure HFrEF treatment

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Relationship of anemia and clinical outcome in heart failure patients with preserved versus reduced ejection fraction in a rural area of Thailand

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Limitations

Cite This Study

Topics

Relationship of anemia and clinical outcome in heart failure patients with preserved versus reduced ejection fraction in a rural area of Thailand

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider