Key result
Suboptimal antihypertensive adherence is linked to ~62% higher risk of conversion to mild cognitive impairment.
Why the study?
Suboptimal medication adherence may be a modifiable risk factor for mild cognitive impairment due to its relationship with systolic blood pressure and blood pressure variability.
Does suboptimal antihypertensive medication adherence increase the risk of mild cognitive impairment in older adults with treated hypertension?
Cohort (n=7,371)
Yes
Does suboptimal antihypertensive medication adherence increase the risk of mild cognitive impairment in older adults with treated hypertension?
Hazard Ratio: 1.62
p-value: p=0.00004
Suboptimal adherence to antihypertensive medications is an independent, modifiable risk factor for mild cognitive impairment, partially mediated by increased systolic blood pressure and blood pressure variability.
May support adherence monitoring in older hypertensives; leaves open whether optimization reduces MCI conversion.
Key Words: blood pressure ■ cognitive dysfunction ■ medication adherence ■ vital signs Lohman and NationMed Adherence, Blood Pressure Variability, and MCI suggest that suboptimal medication adherence is a modifiable risk factor for MCI conversion, due to its relationship with systolic BP and BPV.
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Lohman et al. (2026) conducted a cohort in Hypertension (n=7,371). Suboptimal medication adherence (≤90% adherence) vs. Optimal medication adherence (>90% adherence) was evaluated on Mild cognitive impairment (MCI) conversion (HR 1.62, p=0.00004). Suboptimal medication adherence was associated with a significantly increased risk of mild cognitive impairment conversion (HR 1.62, P=0.00004).
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