Key result
Halothane impairs neonatal myocardial function without altering high-energy phosphates or intracellular pH.
Why the study?
The neonatal heart is especially vulnerable to cardiac depression caused by halothane, but the cause of this sensitivity is uncertain.
Answers are grounded in this paper and cite their sources.
Halothane depresses neonatal heart function without altering HEP or pH; leaves open alternative mechanisms and should not change practice.
The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellular pH mediated the effects of halothane. Steady-state HEP concentrations and intracellular pH were unaffected, despite profound reductions of mechanical performance. The data also suggest that halothane, in the concentrations studied, does not cause significant uncoupling of oxidative phosphorylation.
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McAuliffe et al. (1987) studied Cardiac depression caused by halothane. Halothane was evaluated on Steady-state concentrations of high energy phosphates (HEP) and intracellular pH. Halothane caused profound reductions in mechanical performance in neonatal rabbit hearts without affecting steady-state high-energy phosphate concentrations or intracellular pH.
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