Key result
Exercise training improves skeletal muscle performance in HF by counteracting adverse molecular alterations.
Why the study?
Classical parameters of left ventricular performance do not predict exercise tolerance in chronic heart failure, highlighting the importance of skeletal muscle alterations.
Skeletal muscle alterations limit exercise capacity in CHF beyond LV performance; extends focus to peripheral targets but leaves open need for targeted trials.
Chronic heart failure (CHF) is a condition characterized by exercise intolerance. The level of activity tolerated by an individual cannot be predicted by classical parameters of left ventricular performance. Therefore, considerable attention has been focused on the role of peripheral factors such as skeletal muscle, which are determinants of work capacity. In recent years, many alterations in the skeletal muscle have been described in patients with chronic heart failure. This knowledge has dramatically changed the treatment of patients with CHF. Previously, patients were asked to avoid excessive strain and physical exercise. Recently, however, patients are asked to participate in a supervised physical training program to increase their exercise capacity and to counteract the molecular changes occurring in the skeletal muscle. This review will focus on molecular and biochemical alterations especially in the skeletal muscle and how these alterations are influenced by exercise training finally contributing to better skeletal muscle performance.
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Volker Adams (2007) conducted a review in Chronic heart failure. Physical exercise was evaluated. Physical exercise training in patients with chronic heart failure counteracts molecular and biochemical alterations in skeletal muscle, contributing to better skeletal muscle performance.