April 19, 2012Catheterization and Cardiovascular Interventions

Retrospective multicenter observational study of the interventional management of coronary disease in the very elderly: The NINETY

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Coronary disease (n=146). Intervention: Percutaneous coronary intervention (PCI) with stent implantation vs. Comparison by clinical setting (stable angina vs NSTEMI vs STEMI). Primary outcome: Long-term rate of net adverse cardiac events (NACE: death, MI, target lesion revascularization, and life-threatening or major bleedings) (p=0.32).

Q: What does this research mean for the field?

In nonagenarians undergoing percutaneous coronary intervention, long-term net adverse cardiac events occur in 33.3% of stable patients, 49.3% of NSTEMI patients, and 50.0% of STEMI patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

PCI shows similar long-term NACE rates across stable CAD, NSTEMI, and STEMI in nonagenarians.

P=0.32
n=146

Why the study?

There is a paucity of data among nonagenarians undergoing PCI, motivating the description of outcomes in this population.

Comparison

Clinical settings: stable angina or silent ischemia vs unstable angina or non-ST elevation MI vs STEMI

Design

Retrospective multicenter observational study

Follow-up

Median 24 months

Authors

DSDario SillanoOspedale Maria Vittoria CRChiara ResminiSchool of the Art Institute of Chicago EMEmanuele MeligaInterventional / Structural Cardiology

Discussion

Member takes

Implication

PCI feasible in selected nonagenarians; leaves open optimal selection and need for prospective trials.

Study Design

Type

Observational (n=146)

Multicenter

Yes

PICO

Population

146 consecutive patients aged 90 years or older undergoing percutaneous coronary intervention with stent implantation, followed for a median of 24 months.

Exposure / Comparator

Percutaneous coronary intervention (PCI) with stent implantation vs Comparison by clinical setting (stable angina vs NSTEMI vs STEMI)

Primary Outcome

Long-term rate of net adverse cardiac events (NACE: death, MI, target lesion revascularization, and life-threatening or major bleedings), p=0.32

Main Result

p-value: p=0.32

Cite This Study

Sillano et al. (2012) conducted an observational in Coronary disease (n=146). Percutaneous coronary intervention (PCI) with stent implantation vs. Comparison by clinical setting (stable angina vs NSTEMI vs STEMI) was evaluated on Long-term rate of net adverse cardiac events (NACE: death, MI, target lesion revascularization, and life-threatening or major bleedings) (p=0.32). In nonagenarians undergoing PCI, long-term NACE occurred in 33.3% of stable patients, 49.3% of NSTEMI patients, and 50% of STEMI patients (P=0.32).

synapsesocial.com/papers/6ac492aeb52da6d95246771c https://doi.org/10.1002/ccd.24406

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Retrospective multicenter observational study of the interventional management of coronary disease in the very elderly: The NINETY

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Retrospective multicenter observational study of the interventional management of coronary disease in the very elderly: The NINETY

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Also Consider

Also Consider