Key result
Elevated PA pressure in septal defects is linked to severe dyspnea and impaired lung compliance.
Why the study?
Pulmonary function abnormalities and their relationship to pulmonary artery pressure and dyspnea severity in patients with intracardiac septal defects were not fully characterized.
Observational (n=45)
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High PAP may drive dyspnea and low compliance in septal defects; leaves open whether pressure reduction preserves lung function.
Colin R. Woolf (1963) conducted an observational in Atrial or ventricular septal defect (n=45). High pulmonary artery pressure was evaluated on Pulmonary function and dyspnea. High pulmonary artery pressure in adults with intracardiac septal defects was associated with moderate to severe dyspnea, low lung compliance, and high nonelastic resistance.
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