Key result
Adult patients with small, unrepaired atrial septal defects had significantly lower peak oxygen uptake compared to healthy controls (open: 31.7 mL/kg/min, closed: 29.7 mL/kg/min vs controls: 42.6 mL/kg/min; p=0.0001).
Why the study?
Adult patients with small, unrepaired atrial septal defects have increased risks of pneumonia, atrial fibrillation, stroke, and higher late mortality, but their functional capacity is unknown.
Does a small unrepaired atrial septal defect impair exercise capacity in adults compared to healthy controls?
Population
32 adult patients with small, unrepaired atrial septal defects and 16 healthy matched controls
Comparison
Open or spontaneously closed unrepaired atrial septal defects vs healthy controls
Design
Cross-sectional study
Authors
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Impaired exercise capacity in adults with small unrepaired ASDs may warrant clinical attention; leaves open whether closure improves outcomes.
Cross-Sectional (n=48)
Outcome assessor blinded
No
Does a small unrepaired atrial septal defect impair exercise capacity in adults compared to healthy controls?
Absolute Event Rate: 31.7% vs 42.6%
p-value: p=0.0001
Adults with a history of small, unrepaired atrial septal defects exhibit significantly impaired exercise capacity compared to healthy peers, even if the defect has spontaneously closed.
Udholm et al. (2018) conducted a cross-sectional in Small, unrepaired atrial septal defects (n=48). Small, unrepaired atrial septal defect vs. Healthy controls was evaluated on Peak oxygen uptake (p=0.0001). Adult patients with small, unrepaired atrial septal defects had significantly lower peak oxygen uptake compared to healthy controls (open: 31.7 mL/kg/min, closed: 29.7 mL/kg/min vs controls: 42.6 mL/kg/min; p=0.0001).
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