Key result
Infiltration with adrenaline 1:80,000 showed no dramatic differences compared to saline alone for blood loss, operative time, and operative field condition during septoplasty.
Why the study?
Vasoconstrictor agents are often used to reduce bleeding in surgery but their safety and efficacy compared to saline infiltration in septoplasty is uncertain.
Small cohort finds no dramatic adrenaline-saline difference in septoplasty bleeding; leaves open need for larger randomized trials.
Vasoconstrictor agents are often used to reduce bleeding and hence improve the operative field in surgery. These agents are potentially dangerous. A trial was undertaken to compare the use of adrenaline 1:80,000 with saline alone as an infiltrating agent in 30 consecutive patients undergoing septoplasty under general anaesthesia. This study, based on a small number of patients can draw no firm conclusions. There are no really dramatic differences between 1:80,000 adrenaline and saline, in terms of blood loss, operative time and the condition of the operative field between the two groups. However, there is a possibility that there are substantial differences which, because of the variability of these outcomes, could not be detected in a study as small as this. It is recommended that a randomized trial involving patients is used to answer the question.
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I Vanniasegaram (1991) studied Patients undergoing septoplasty (n=30). Adrenaline vs. Saline alone was evaluated on Blood loss, operative time, and condition of the operative field. Infiltration with adrenaline 1:80,000 showed no dramatic differences compared to saline alone for blood loss, operative time, and operative field condition during septoplasty.
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