Why the study?
Does submucosal infiltration of adrenaline compared to topical instillation increase plasma adrenaline concentrations in patients undergoing elective nasal surgery?
Population
20 patients undergoing elective nasal surgery
Comparison
Submucosal infiltration of 4.4 ml of 1:80,000… vs Instillation of solution containing 1 ml of…
Design
Cohort
Follow-up
intraoperative
Authors
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Infiltration may raise systemic exposure risk in vulnerable patients; leaves open optimal route balancing absorption and field quality.
Does submucosal infiltration of adrenaline compared to topical instillation increase plasma adrenaline concentrations in patients undergoing elective nasal surgery?
Submucosal infiltration of adrenaline during nasal surgery results in significantly higher systemic absorption and peak plasma adrenaline levels compared to topical instillation, though it provides a better operative field.
Hasselt et al. (1992) studied this question.
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