Key result
Lignocaine-adrenaline infiltration increases plasma adrenaline to ~1.72 pmol/ml at 2 minutes versus prilocaine-octapressin.
Why the study?
Does submucous infiltration with lignocaine/adrenaline compared to prilocaine/octapressin affect plasma catecholamine concentrations in patients?
RCT (n=19)
Randomized
Does submucous infiltration with lignocaine/adrenaline compared to prilocaine/octapressin affect plasma catecholamine concentrations in patients?
Submucous infiltration with lignocaine/adrenaline causes a rapid, transient increase in plasma adrenaline compared to prilocaine/octapressin.
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Caution with lignocaine-adrenaline in cardiac-risk patients; extends RCT evidence on vasoconstrictor effects during dental anaesthesia.
Taylor et al. (1984) reported an RCT. 0.5% lignocaine with adrenaline 1:200 000 vs. 0.5% prilocaine with octapressin 0.03 iu per ml was evaluated on Plasma adrenaline concentration at 2 minutes. Submucous infiltration with lignocaine and adrenaline increased plasma adrenaline to 1.72 pmol/ml at 2 minutes, whereas prilocaine with octapressin caused no similar peak.
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