Why the study?
Does the composition of scalp infiltration solutions (epinephrine with or without lidocaine) affect cardiovascular responses in neurosurgical patients undergoing craniotomy?
Does the composition of scalp infiltration solutions (epinephrine with or without lidocaine) affect cardiovascular responses in neurosurgical patients undergoing craniotomy?
Epinephrine used for scalp infiltration during craniotomy causes significant hypertension and tachycardia, which is attenuated by the addition of lidocaine but results in a biphasic hypotensive response.
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May prompt caution with epinephrine-only scalp infiltration in craniotomy; leaves open optimal formulation for randomized trials.
Murthy et al. (2001) studied this question.
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