Key result
Diabetes and diabetic cardiomyopathy linked to higher severe COVID-19 risk through convergent inflammation.
Why the study?
Patients with preexisting cardiovascular disease who develop COVID-19 have worse outcomes, and the relationship between COVID-19 and heart failure with preserved ejection fraction (HFpEF) requires elucidation.
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May warrant closer monitoring for severe COVID-19 in diabetes; leaves open causal HFpEF mechanisms post-infection.
Freaney et al. (2020) conducted a review in COVID-19, Heart Failure with Preserved Ejection Fraction, and Diabetic Cardiomyopathy. Patients with diabetes or diabetic cardiomyopathy face significantly higher risks of severe COVID-19 outcomes due to convergent metabolic dysregulation, endothelial injury, and inflammation.
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