Key result
Aerobic exercise plus resveratrol increases myocardial AMPK and reduces MAFbx expression in diabetic rats.
Why the study?
Diabetes is associated with heart injury, and the effects of aerobic exercise combined with resveratrol on myocardial AMPK and MAFbx gene expression in diabetic subjects are not well understood.
Answers are grounded in this paper and cite their sources.
May support pathway modulation in diabetic cardiomyopathy models; hypothesis-generating and leaves open clinical translation.
Background and Aim: Diabetes is a metabolic disease that is associated with heart injury. It has been shown that exercise training and resveratrol can improve the cardiac structure and function of diabetic subjects. The aim of the present study was to examine the effect of aerobic training along with resveratrol on gene expression of AMPK and MAFbx on myocardial AMPK and MAFbx gene expression of diabetic rats. Materials and Methods: In this experimental study, 40 males Wistar rats were randomly were divided into 5 groups: control (CN), diabetes (DM), diabetes-Resveratrol (RDM), diabetes-aerobic exercise (TDM), diabetes-aerobic exercise-Resveratrol (RTDM).Training groups have performed a running program on the treadmill for 8 weeks. Resveratrol (20 mg/kg) was injected subcutaneously 8 weeks for RDM and TRDM groups. 48 hours after the last training session, rats were anesthetized. Changes in the expression of AMPK and MAFbx myocardial genes were quantified using real-time PCR methods. Results: The results of the present study showed a reduction in AMPK expression (P < 0.001) and an increase in MAFbx (P < 0.001) in cardiomyocytes in DM groups compared to CN group. AMPK expression was significantly increased in TRDM group compared to DM (p=0.009), RDM (p=0.011) and TDM (p=0.043) groups. MAFbx expression of cardiomyocytes in RDM (p=0.012), TDM (p<0.001) and TRDM (p<0.001) groups had significantly reduction compared to DM group. Also, MAFbx expression was significantly reduction in TRDM groups compared to RDM (p=0.041) groups. Conclusion: Long-term aerobic exercise, with and without resveratrol consumption it may cause to reduce the genomic indicators of atrophy and increase myocardial hypertrophy in diabetic rats.
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A 2020 study studied Diabetes (n=40). Aerobic exercise and resveratrol vs. Diabetic control, healthy control, exercise alone, resveratrol alone was evaluated on Myocardial AMPK and MAFbx gene expression (p=0.009). Long-term aerobic exercise combined with resveratrol supplementation increased myocardial AMPK expression and reduced MAFbx expression compared to diabetic controls in rats.
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