Key result
Proposed protocol updates optimize blood pressure assessment in the Salt Substitute in India Study.
Why the study?
The Salt Substitute in India Study (SSiIS) was designed to assess the impact of substituting usual salt with a salt substitute on blood pressure.
Protocol for Indian salt-substitute RCT described; extends prior work but leaves open BP-variability effects until results emerge.
To the Editor: We read with pleasure the article by Thout et al, titled “Rationale, design, and baseline characteristics of the Salt Substitute in India Study (SSiIS): The protocol for a double-blinded, randomized-controlled trial”1 that described a trial assessing the impact of substituting usual salt (100% sodium chloride) with salt substitute (70% sodium chloride and 30% potassium chloride) on blood pressure (BP). Upon comparison with related trials and in context of recent research on BP variability, we propose the following modifications to maximize the potential of the trial: The authors declare that they have no competing interests. This study was exempt from Rutgers's Institutional Review Board approval. No funding provided for this study.
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Visaria et al. (2020) conducted a letter in Blood pressure. Salt substitute (70% sodium chloride and 30% potassium chloride) vs. Usual salt (100% sodium chloride) was evaluated on Blood pressure. This letter proposes modifications to the Salt Substitute in India Study protocol to maximize its potential in evaluating the effect of salt substitution on blood pressure.
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