Key result
Asymptomatic carotid bruit is linked to more than double the expected stroke risk over 8 years.
Why the study?
The clinical significance of asymptomatic carotid bruit as a predictor of stroke risk and its relation to local arterial stenosis versus general atherosclerotic disease was unclear.
Population
171 asymptomatic men and women with carotid bruit in the Framingham cohort
Comparison
Subjects with asymptomatic carotid bruit versus general population risk
Design
Prospective cohort study
Authors
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Asymptomatic carotid bruits associate with >2-fold stroke risk; leaves open whether detection alters management or outcomes.
Cohort (n=171)
Effect estimate: more than twice expected
P. A. Wolf (1981) conducted a cohort in Asymptomatic carotid bruit (n=171). Asymptomatic carotid bruit vs. Expected rate for age and sex was evaluated on Stroke (more than twice expected). Asymptomatic carotid bruit was associated with a stroke rate more than twice that expected for age and sex (12.3% over 8 years), serving as a general marker of advanced atherosclerotic disease.
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