Key result
Preoperative LVESD linked to ~18% higher risk of postoperative LV dysfunction after mitral repair.
Why the study?
Preoperative LVESD and LVEF cut-off values used in guidelines for predicting LV dysfunction after MV repair have received little validation in Japanese patients with degenerative mitral regurgitation.
Do preoperative echocardiographic indices (LVESD and LVEF) predict postoperative left ventricular dysfunction in Japanese patients undergoing mitral valve repair for degenerative mitral regurgitation?
Cohort (n=322)
Yes
Do preoperative echocardiographic indices (LVESD and LVEF) predict postoperative left ventricular dysfunction in Japanese patients undergoing mitral valve repair for degenerative mitral regurgitation?
Odds Ratio: 1.183 (95% CI 1.083–1.303)
p-value: p=<0.001
In Japanese patients undergoing mitral valve repair for degenerative mitral regurgitation, a preoperative LVESD cut-off of 36 mm better predicts postoperative LV dysfunction than the current guideline cut-off of 40 mm.
Background: Left ventricular (LV) dysfunction after mitral valve (MV) repair for degenerative mitral regurgitation (DMR) is a poor prognostic factor. Preoperative LV end-systolic diameter (LVESD) and LV ejection fraction (LVEF) are used in guidelines as indices for LV dysfunction, with cut-off values of 60% for LVEF and 40 mm for LVESD. However, these factors have received little validation in Japanese patients. Methods and Results: We evaluated preoperative echocardiographic data in 322 Japanese patients who underwent MV repair for DMR to identify factors associated with postoperative LV dysfunction. Postoperative LV dysfunction was observed in 31 (10%) patients, who had greater LVESD (39±6 mm vs. 33±5 mm; P<0.001) and lower LVEF (62±5% vs. 67±5%; P<0.001) preoperatively, compared with the non-LV dysfunction group. The optimal threshold of preoperative LVESD and LVEF for predicting postoperative LV dysfunction in receiver operating characteristic curve analysis was 36 mm (AUC=0.819; P<0.001) and 61% (AUC=0.706; P<0.001), respectively. Kaplan-Meier analysis showed a significantly lower rate of avoided adverse cardiac events in the LV dysfunction group (P<0.001). Conclusions: The criteria for LVESD in MV repair in patients with DMR should be lower than the values indicated by the guidelines. Adoption of these revised criteria may improve prognosis after surgery in Japanese patients.
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Yoshida et al. (2025) conducted a cohort in Degenerative mitral regurgitation (n=322). Preoperative left ventricular end-systolic diameter (LVESD) vs. Lower LVESD was evaluated on Postoperative left ventricular dysfunction (LVEF <50% at 6-12 months) (OR 1.183, 95% CI 1.083-1.303, p=<0.001). Preoperative left ventricular end-systolic diameter was an independent predictor of postoperative left ventricular dysfunction after mitral valve repair (OR 1.183), with an optimal cut-off of 36 mm.
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