Key result
Deep learning IVUS segmentation achieves strong agreement with expert manual measurements with ~0.86 ICC.
Why the study?
The generalization performance and consistency of deep learning segmentation models for IVUS lumen and EEM segmentation on large cohorts were not well established.
Do deep learning segmentation models accurately segment the lumen and external elastic membrane in IVUS images compared to manual segmentation by cardiologists?
Cohort (n=113)
No
Do deep learning segmentation models accurately segment the lumen and external elastic membrane in IVUS images compared to manual segmentation by cardiologists?
Effect estimate: ICC 0.855 (95% CI 0.822-0.887)
Deep learning models can achieve state-of-the-art results in IVUS lumen and EEM segmentation with excellent agreement to manual measurements by clinicians.
May support automated IVUS measurements in research; leaves open prospective validation before clinical adoption.
OBJECTIVES: The aim of this study was to investigate the generalization performance of deep learning segmentation models on a large cohort intravascular ultrasound (IVUS) image dataset over the lumen and external elastic membrane (EEM), and to assess the consistency and accuracy of automated IVUS quantitative measurement parameters. METHODS: A total of 11,070 IVUS images from 113 patients and pullbacks were collected and annotated by cardiologists to train and test deep learning segmentation models. A comparison of five state of the art medical image segmentation models was performed by evaluating the segmentation of the lumen and EEM. Dice similarity coefficient (DSC), intersection over union (IoU) and Hausdorff distance (HD) were calculated for the overall and for subsets of different IVUS image categories. Further, the agreement between the IVUS quantitative measurement parameters calculated by automatic segmentation and those calculated by manual segmentation was evaluated. Finally, the segmentation performance of our model was also compared with previous studies. RESULTS: CENet achieved the best performance in DSC (0.958 for lumen, 0.921 for EEM) and IoU (0.975 for lumen, 0.951 for EEM) among all models, while Res-UNet was the best performer in HD (0.219 for lumen, 0.178 for EEM). The mean intraclass correlation coefficient (ICC) and Bland-Altman plot demonstrated the extremely strong agreement (0.855, 95% CI 0.822-0.887) between model's automatic prediction and manual measurements. CONCLUSIONS: Deep learning models based on large cohort image datasets were capable of achieving state of the art (SOTA) results in lumen and EEM segmentation. It can be used for IVUS clinical evaluation and achieve excellent agreement with clinicians on quantitative parameter measurements.
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Dong et al. (2023) conducted a cohort in Coronary artery disease (n=113). Deep learning-based image segmentation models vs. Manual segmentation by cardiologists was evaluated on Agreement between automatic prediction and manual measurements (ICC 0.855, 95% CI 0.822-0.887). Deep learning-based segmentation models achieved state-of-the-art performance in intravascular ultrasound image segmentation, demonstrating extremely strong agreement (mean ICC 0.855) with manual clinical measurements.
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