Izoxinolin alkaloidlaridan olingan 1-(4-dimetilaminofenil)-6,7-dimetoksi-1,2,3,4-tetragidroizoxinolinning yurak mitoxondriyalarining ATFga bog‘liq kaliy kanallariga ta’siri

Q: What is the clinical evidence from this study?

Population: In vitro study of rat heart mitochondria. Intervention: Isoquinoline alkaloid 1-(4-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-24) vs. Diazoxide. Primary outcome: Effect on ATP-dependent potassium channel (mitoKATP) permeability.

Q: What does this research mean for the field?

The isoquinoline alkaloid derivative F-24 concentration-dependently activates rat cardiac mitochondrial ATP-sensitive potassium channels in the presence of ATP and enhances channel permeability synergistically with diazoxide. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Иродахон МУХАМЕДИЕВА; Sadokat Mullajonova; Сhamankhon Abdukakhorova; Иродахон МУХАМЕДИЕВА; Садокат Муллажонова; Сhamankhon Abdukakhorova; Irodaxon Muxamediyeva; Sadokat Mullajonova; Chamanxon Abduqahorova

doi:10.47689/2181-3663-vol4-iss6-pp212-218

December 20, 2025Профилактическая медицина и здоровьеOpen Access

Izoxinolin alkaloidlaridan olingan 1-(4-dimetilaminofenil)-6,7-dimetoksi-1,2,3,4-tetragidroizoxinolinning yurak mitoxondriyalarining ATFga bog‘liq kaliy kanallariga ta’siri

View Full Paper

Ask AI

Bookmark

Share

Why the study?

The concentration-dependent effect of the isoquinoline alkaloid F-24 on the ATP-dependent potassium channel of rat heart mitochondria was not previously characterized.

Structured PICO

P

Population

Rat heart mitochondria isolated using differential centrifugation method (in vitro)

I

Intervention

Isoquinoline alkaloid 1-(4-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-24) at 5-20 μM concentrations

C

Comparator

Diazoxide (mitoKATP channel activator) and baseline (presence of ATP)

O

Outcome

Permeability of the ATP-dependent potassium channel (mitoKATP) of rat heart mitochondriasurrogate

Implication

The isoquinoline alkaloid F-24 activates mitochondrial ATP-dependent potassium channels in rat hearts in vitro, demonstrating an additive effect when combined with diazoxide.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

МУХАМЕДИЕВА et al. (2025) studied In vitro study of rat heart mitochondria. Isoquinoline alkaloid 1-(4-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-24) vs. Diazoxide was evaluated on Effect on ATP-dependent potassium channel (mitoKATP) permeability.

synapsesocial.com/papers/6ac591f938c9af7ead3834e0 https://doi.org/10.47689/2181-3663-vol4-iss6-pp212-218

View Full Paper

Ask AI

Bookmark

Share

Izoxinolin alkaloidlaridan olingan 1-(4-dimetilaminofenil)-6,7-dimetoksi-1,2,3,4-tetragidroizoxinolinning yurak mitoxondriyalarining ATFga bog‘liq kaliy kanallariga ta’siri

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Izoxinolin alkaloidlaridan olingan 1-(4-dimetilaminofenil)-6,7-dimetoksi-1,2,3,4-tetragidroizoxinolinning yurak mitoxondriyalarining ATFga bog‘liq kaliy kanallariga ta’siri

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading