Key result
Dofetilide and d-sotalol block the ATP-sensitive potassium channel, with dofetilide requiring high concentrations (EC50 51 µM) and d-sotalol showing a 42% reduction at 10 µM.
Why the study?
Do dofetilide and d-sotalol block the ATP-sensitive potassium channel in rabbit ventricular myocytes?
Do dofetilide and d-sotalol block the ATP-sensitive potassium channel in rabbit ventricular myocytes?
Dofetilide and d-sotalol block the ATP-sensitive potassium channel in rabbit ventricular myocytes, with d-sotalol showing modest blockade at clinically relevant concentrations.
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Should not yet change arrhythmia management; leaves open translational relevance of KATP effects in humans.
West et al. (1996) studied this question. Dofetilide and d-sotalol was evaluated on Activity of I(KATP) channels. Dofetilide and d-sotalol block the ATP-sensitive potassium channel, with dofetilide requiring high concentrations (EC50 51 µM) and d-sotalol showing a 42% reduction at 10 µM.
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