Why the study?
Does dofetilide or D-sotalol maintain their class III antiarrhythmic action during simulated metabolic acidosis in isolated guinea pig ventricular muscle?
Does dofetilide or D-sotalol maintain their class III antiarrhythmic action during simulated metabolic acidosis in isolated guinea pig ventricular muscle?
Metabolic acidosis, a major component of myocardial ischemia, does not attenuate the class III antiarrhythmic action of dofetilide and D-sotalol in isolated guinea pig ventricular muscle.
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Maintains class III effects in acidic guinea pig muscle; hypothesis-generating for ischemic arrhythmias, requires in vivo and clinical validation.
Yang et al. (1992) studied this question.
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