November 1, 1992Cardiovascular Research

Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes

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Why the study?

Does dofetilide attenuate hypoxia-induced electromechanical changes in isolated guinea pig ventricular muscle?

Structured PICO

Does dofetilide attenuate hypoxia-induced electromechanical changes in isolated guinea pig ventricular muscle?

Population

Isolated guinea pig right ventricular papillary muscles (n=34)

Intervention

Pretreatment for 30 min with 0.1 microM dofetilide prior to hypoxia or nicorandil exposure

Comparator

Pretreatment with 100 microM glibenclamide or no pretreatment (drug-free)

Outcome

Transmembrane action potentials (APD90, effective refractory period) and developed forcesurrogate

Dofetilide attenuates hypoxia-induced action potential shortening and reduction in contractile force in isolated guinea pig ventricular muscle, suggesting it may retain antiarrhythmic efficacy during myocardial ischemia.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for dofetilide in ischemic arrhythmias; should not yet change clinical practice.

Cite This Study

Yang et al. (1992) studied this question.

synapsesocial.com/papers/6a821de71fb4be735b3f0d0a https://doi.org/10.1093/cvr/26.11.1109

View Full Paper

Ask AI

Bookmark

Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes

Structured PICO

Discussion

Implication

Cite This Study

Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider