A short and convergent synthesis of pyrrolophenanthridone alkaloids, such as anhydrolycorin-7-one, oxoassoanine, hippadine, and prastosine, was developed by using directed lithiation and palladium-catalyzed cross-coupling as key reactions. Anhydrolycorin-7-one was converted to an antitumor alkaloid, kalbretorine, via directed lithiation and hydro- xylation reactions
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Iwao et al. (1994) studied this question.
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