11S9fication of a disease-producing microphyte is the faculty of living and multiplying in the living tissue, the researches of recent years have taucght us that its poisonousness is even more essential than its adaptedness to a living nutritive me- dium; so much so that the damage which it thereby inflicts on its living environment is a means by which it modifies that environment for its own advantage.We have further seen that the contest whiclh takes place in the organism be- tween invading microphytes and the living elements of the
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V. Horsley (1891) studied this question.