Key result
Hypertension is linked to ~15-fold higher odds of cardiac valve calcification in rheumatoid arthritis.
Why the study?
Cardiovascular disease remains a major cause of mortality in rheumatoid arthritis patients, necessitating early diagnosis and risk prediction of cardiac valve calcification.
Population
350 rheumatoid arthritis patients with and without cardiac valve calcification
Comparison
RA patients with cardiac valve calcification vs without cardiac valve calcification
Design
Case-control study with LASSO and logistic regression analyses
Authors
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Hypertension may flag RA patients for valve evaluation; leaves open whether screening or BP control alters calcification or outcomes.
Observational (n=350)
No
Odds Ratio: 15.496 (95% CI 4.373–54.916)
p-value: p=<0.01
T. Bonfiglio (1969) conducted an observational in Rheumatoid arthritis (n=350). Hypertension vs. Normotension (no hypertension) was evaluated on Presence of cardiac valve calcification (CVC) (OR 15.496, 95% CI 4.373-54.916, p=<0.01). In patients with rheumatoid arthritis, comorbid hypertension was strongly and independently associated with the presence of cardiac valve calcification (OR 15.496) and served as a key predictor in a highly accurate nomogram.
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