Key result
DDT partitions from chylomicrons to adipocytes faster than triacylglycerol without requiring chylomicron hydrolysis.
Why the study?
The mechanism by which DDT is delivered from lymphatic chylomicrons to adipose tissue has not been explored and differs from non-physiological delivery methods.
Population
Male rats and murine 3T3-L1 adipocytes
Comparison
14C-DDT in lymph-derived chylomicrons vs 3H-triglyceride or DDT delivered via DMSO
Design
Preclinical experimental study
Authors
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Rapid DDT partitioning to adipocytes without lipolysis is hypothesis-generating; leaves open human toxicokinetic relevance and clinical implications.
DDT is rapidly absorbed and transported to adipocytes via chylomicrons in a process distinct from triglyceride uptake, highlighting a specific toxicokinetic pathway for lipophilic compounds.
Pocock et al. (1974) studied this question. DDT in chylomicrons vs. DMSO vehicle or Triacylglycerol-3H was evaluated on Uptake of DDT by adipocytes. DDT partitions from chylomicrons to adipocytes more rapidly than triacylglycerol, and this transport does not require hydrolysis of the chylomicron.
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