Key result
Cervical vagosympathetic stimulation elicits mixed inhibitory, excitatory, and profound pressor cardiovascular responses.
Why the study?
The cardiovascular effects of cervical vagosympathetic trunk stimulation are complex due to varying parasympathetic, sympathetic, and afferent nerve fiber content and their reflex contributions.
Complex fiber-dependent responses require selective targeting in vagal studies; leaves open optimal parameters for cardiovascular neuromodulation.
Stimulation of the cervical vagosympathetic trunk may elicit either inhibitory or excitatory responses in the heart, or a combination of both, depending upon the varying content of parasympathetic, sympathetic, and afferent nerve fibers. Visceral afferent fibers contribute importantly to reflex feedbacks to the heart, as well as to recruitment of peripheral circulatory and neurohumoral mechanisms of cardiovascular control. Profound pressor responses may be elicited by excitation of afferent fibers within the cervical vagosympathetic trunk.
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Randall et al. (1974) reported a review. Stimulation of the cervical vagosympathetic trunk was evaluated. Stimulation of the cervical vagosympathetic trunk elicits complex inhibitory, excitatory, and profound pressor cardiovascular responses depending on parasympathetic, sympathetic, and afferent fiber content.
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