Key result
Exercise confers cardioprotection, but optimal dose, intensity, and underlying molecular mechanisms remain undefined.
Why the study?
Despite known cardiovascular benefits of exercise, critical questions remain about the amount, intensity, and signaling pathways underlying exercise-induced cardioprotective adaptations.
Supports ongoing exercise recommendations in cardiovascular care; leaves open precise dose, intensity, and pathway optimization.
The benefits of exercise for cardiovascular health and improved cardiovascular disease outcome are undeniable. Experimental, epidemiological and clinical studies support exercise as an effective cardioprotective activity (1). Diverse exercise-induced acute and chronic adaptations have been described as underlying contributors for a cardioprotective phenotype (2). Yet, many questions remain unanswered: is there a critical amount and/or intensity of exercise to trigger the adaptations? Is there one main signaling pathway that orchestrates the resulting phenotype? If so, is it possible to therapeutically stimulate specific signaling pathways and thereby mimic the exercise stimulus?
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Verdoorn et al. (2017) conducted an editorial in Cardiovascular disease. Exercise was evaluated. Exercise provides undeniable cardioprotective benefits, though the critical amount, intensity, and underlying signaling pathways required to trigger these adaptations remain unknown.
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