Key result
Higher sST2 linked to ~2% higher risk of post-MI cardiovascular events.
Why the study?
The possibility of predicting adverse cardiovascular events after myocardial infarction using clinical, instrumental methods, and sST2 was investigated.
Do echocardiographic parameters, coronary angiography scores, and sST2 concentrations predict adverse cardiovascular events in patients after acute myocardial infarction treated with PCI?
Cohort (n=64)
Do echocardiographic parameters, coronary angiography scores, and sST2 concentrations predict adverse cardiovascular events in patients after acute myocardial infarction treated with PCI?
Intermediate ejection fraction, left ventricular aneurysm, high sST2 concentrations, and high Syntax scores are significant predictors of adverse cardiovascular events in post-myocardial infarction patients treated with percutaneous coronary intervention.
Answers are grounded in this paper and cite their sources.
High sST2, intermediate EF, LV aneurysm and SYNTAX score were associated with adverse post-MI outcomes; leaves open validation before clinical risk models.
OBJECTIVE: Aim: To determine the possibility of predicting adverse cardiovascular events based on the analysis of clinical and instrumental research methods, as well as sST2 in patients after myocardial infarction. PATIENTS AND METHODS: Materials and Methods: The study included 64 patients who suffered an acute myocardial infarction and underwent PCI with balloon angioplasty and stenting of the infarct-related vessel in the acute period. The predictors of adverse cardiovascular events were assessed events during 1 year of observation. Indicators of echocardiography and coronary angiography were assessed and concentrations sST2. RESULTS: Results: A worse prognosis was associated with intermediate ejection fraction (EF) (odds ratio (OR)=3.981, p<0.05), left aneurysm ventricle (LV) (OR=29.5, p<0.05), high concentrations of sST2 (OR=1.017, p<0.05) and scores on the Syntax scale (OR=1.001, p<0.05). CONCLUSION: Conclusions: In patients who underwent percutaneous coronary intervention for myocardial infarction, adverse outcome during the next 2 years is associated with coronary and echocardiographic parameters, as well as biochemical indicators of myocardial stress and fibrosis. HF patients with intermediate EF, LV aneurysm, high sST2 concentrations, and high Syntax scores have the worst prognosis.
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Volynskyi et al. (2024) conducted a cohort in Acute myocardial infarction (n=64). High sST2 concentrations, intermediate ejection fraction, left ventricular aneurysm, and high Syntax scores vs. Lower/normal respective values was evaluated on Adverse cardiovascular events (OR 1.017, p=<0.05). Intermediate ejection fraction, LV aneurysm, and high sST2 predicted adverse cardiovascular events after myocardial infarction.
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