Key result
Permanent transvenous RVP reduces platelet count ~32% without altering routine coagulation tests in rabbits.
Why the study?
The influence of pure right-ventricle pacemaker implantation on hematologic and coagulation profiles without medication was unclear.
No immediate clinical implications; leaves open whether right-ventricular pacing alters hematologic parameters in humans.
OBJECTIVES: The aim of this study was to evaluate changes in hematology and coagulation in rabbits with right-ventricle pacing without medication. ANIMALS AND METHODS: Blood was collected from ten non-anesthetized male rabbits from the jugular vein before and one month after pacemaker placement. Total erythrocyte, leukocyte and platelet count, hemoglobin, hematocrit and differential leukocyte count were done on automatic veterinary flow cytometry hematologic analyzer. Prothrombin time, activated partial thromboplastin time, fibrinogen level, D-dimers and kaolin-activated thromboelastography was measured from citrated blood. RESULTS: We found an increase in red blood cell mass and decrease in platelet count, while coagulation tests did not diff er between samplings. CONCLUSION: Right-ventricle pacing seems to have no influence on hemostasis in rabbits.
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Uhríková et al. (2016) studied Healthy (animal model for right-ventricle pacing) (n=10). Permanent transvenous right-ventricle pacing vs. Baseline (before pacemaker placement) was evaluated on Coagulation profile and hematologic changes (e.g., platelet count) (p=<0.01). Permanent transvenous right-ventricle pacing in healthy rabbits led to a significant decrease in platelet count (430 to 294 x 10^9/L, p<0.01) and increase in red blood cell parameters, with no significant alterations in routine coagulation tests.
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