Key result
Transcatheter paravalvular leak closure improves hemolysis markers or hemoglobin in ~42% of patients.
Why the study?
Although transcatheter paravalvular leak closure reduces heart failure and mortality in symptomatic patients, its effect on hemolysis is not well understood.
Cohort (n=168)
No
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May support considering transcatheter PVL closure for hemolysis relief; leaves open need for prospective confirmation, especially in mechanical valves.
Panaich et al. (2018) conducted a cohort in Paravalvular leak with anemia or abnormal hemolysis markers (n=168). Transcatheter paravalvular leak (PVL) closure vs. Pre-procedure baseline was evaluated on Hemoglobin increase ≥ 1.5 mg/dL, decrease in LDH above median, or improvement in haptoglobin. Transcatheter paravalvular leak closure improved hemolysis markers or increased hemoglobin in 42% of patients, with the benefit being most significant in those with mechanical valves.
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