Key result
In a population of 2,666 adolescents, the prevalence of microalbuminuria was 3.3% in both genders and was not associated with cardiometabolic risk markers; conversely, microalbuminuric adolescents tended to be leaner than normoalbuminuric counterparts.
Why the study?
Slovak adolescents are at high risk for early cardiovascular disease, and the association of microalbuminuria with cardiometabolic risk factors in this population is unclear.
Cross-Sectional (n=2,666)
Yes
Answers are grounded in this paper and cite their sources.
Microalbuminuria in adolescents shows no cardiometabolic link and may occur in leaner individuals; hypothesis-generating and should not yet change practice.
INTRODUCTION: In adults, microalbuminuria indicates generalized endothelial dysfunction, and is an independent risk factor for cardiovascular and all cause mortality. Slovak adults present one of the highest cardiovascular mortality rates in Europe. Thus Slovak adolescents are on a high-risk to develop cardiovascular afflictions early, and screening for microalbuminuria might be useful in early assessment of their cardiovascular risk. We aimed to study the prevalence of microalbuminuria in Slovak adolescents, and the association of urinary albumin-to-creatinine ratio (ACR) to cardiovascular risk factors. SUBJECTS AND METHODS: Anthropometric data, blood pressure, blood count, glucose homeostasis, lipid profile, renal function, inflammatory status, concentrations of homocysteine and uric acid were determined and associated with ACR in 2 666 adolescents (49.4% boys, 51.6% girls) aged 14-to-20 years. Microalbuminuria was classified as ACR 2.5-25.0 mg/mmol in boys and 3.5-35.0 mg/mmol in girls. RESULTS: Prevalence of microalbuminuria in both genders reached 3.3%, and did not differ significantly between lean and centrally obese subjects. Girls presented higher ACR than boys (normoalbuminuric: 0.6 ± 0.5 mg/mmol vs. 0.5 ± 0.4 mg/mmol, p > 0.001; microalbuminuric: 9.3 ± 7.3 mg/mmol vs. 5.0 ± 3.8 mg/mmol; p > 0.001). Microalbuminuric adolescents and those presenting normoalbuminuria within the upper ACR quartile were slimmer than their normoalbuminuric counterparts or adolescents with normoalbuminuria within the lower quartile, respectively. No association between microalbuminuria and cardiovascular risk markers was revealed. CONCLUSION: Results obtained in this study do not support our assumption that ACR associates with cardiometabolic risk factors in apparently healthy adolescents. Follow-up studies until adulthood are needed to estimate the potential cardiometabolic risk of apparently healthy microalbuminuric adolescents.
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Gurecká et al. (2015) conducted a cross-sectional in Apparently healthy adolescents (n=2,666). Cardiometabolic risk factors (including central obesity) vs. Absence of cardiometabolic risk factors / Lean stature was evaluated on Association between microalbuminuria and cardiometabolic risk factors. In a population of 2,666 adolescents, the prevalence of microalbuminuria was 3.3% in both genders and was not associated with cardiometabolic risk markers; conversely, microalbuminuric adolescents tended to be leaner than normoalbuminuric counterparts.
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