December 31, 2007PEDIATRICS

Being Overweight Modifies the Association Between Cardiovascular Risk Factors and Microalbuminuria in Adolescents

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Why the study?

Does being overweight modify the association between cardiovascular risk factors and microalbuminuria in adolescents?

Population

2,515 adolescents 12 to 19 years of age from the National Health and Nutrition Examination Survey (1999-2004)

Comparison

Presence of cardiovascular risk factors and… vs Absence of cardiovascular risk factors and…

Design

Cross-sectional

Authors

SNStéphanie NguyenMorgan Stanley Children's Hospital CMCharles E. McCullochSemmelweis University PBPaul BrakemanUniversity of California, San Francisco

Discussion

Member takes

Implication

BMI may modify microalbuminuria–risk factor links in adolescents; hypothesis-generating and should not yet change practice.

Structured PICO

Does being overweight modify the association between cardiovascular risk factors and microalbuminuria in adolescents?

Population

2,515 adolescents 12 to 19 years of age from the National Health and Nutrition Examination Survey (1999-2004)

Intervention

Presence of cardiovascular risk factors (abdominal obesity, impaired fasting glucose, diabetes mellitus, insulin resistance, high triglyceride levels, low high-density lipoprotein cholesterol levels, hypertension, smoking, and the metabolic syndrome) and overweight status (BMI ≥ 95th percentile)

Comparator

Absence of cardiovascular risk factors and nonoverweight status

Outcome

Microalbuminuria (urinary albumin/creatinine ratio of 30 to 299 mg/g in a random morning sample)surrogate

In adolescents, microalbuminuria is associated with cardiovascular risk factors primarily among those who are overweight, suggesting that BMI modifies this relationship.

Limitations

Prognostic importance of microalbuminuria in overweight and nonoverweight adolescents with regard to future cardiovascular and renal disease needs to be defined in prospective studies

Cite This Study

Nguyen et al. (2007) studied this question.

synapsesocial.com/papers/6a88f215c80974a9031a1e1a https://doi.org/10.1542/peds.2007-3594

Topics

Women and heart disease

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Being Overweight Modifies the Association Between Cardiovascular Risk Factors and Microalbuminuria in Adolescents

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Being Overweight Modifies the Association Between Cardiovascular Risk Factors and Microalbuminuria in Adolescents

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider