Key result
Hemodialysis patients show ~31% prevalence of aortic valve calcification, with higher rates after age 40.
Why the study?
Valvular calcification is a significant cardiovascular complication in ESRD patients, but local data on its prevalence are scarce.
Cross-Sectional (n=140)
No
There is a substantial prevalence of mitral (30.7%) and aortic (31.4%) valve calcification in young ESRD patients on maintenance hemodialysis, particularly driven by patients over the age of 40.
Valvular calcification affects ~30% of ESRD patients on hemodialysis, rising after age 40; leaves open whether routine screening improves outcomes.
Background and Objective: Valvular calcification is a significant cardiovascular complication in patients with end-stage renal disease (ESRD), yet local data regarding its prevalence remain scarce.To determine the frequency of mitral valve calcification (MVC) and aortic valve calcification (AVC) in patients with ESRD on maintenance hemodialysis. Study Design: Cross-sectional survey. Setting: Department of Cardiology, Jinnah Hospital, Lahore. Subjects & Methods: A total of 140 patients (both genders) diagnosed with ESRD for at least three months and undergoing maintenance hemodialysis were enrolled. Demographic data, including age, gender, and duration of ESRD, were recorded. Transthoracic echocardiography was performed on all subjects to identify the presence of MVC and AVC. Results: The mean age of the study population was 39.24 ± 11.31 years. The cohort consisted of 89 (63.6%) males and 51 (36.4%) females. MVC was detected in 43 patients (30.7%), while AVC was present in 44 patients (31.4%). While gender and the duration of ESRD did not show a significant correlation with calcification, advancing age was significantly associated with the presence of both MVC and AVC ($p < 0.05$). Conclusion: There is a high prevalence of mitral and aortic valve calcification among ESRD patients in our population. Given the associated cardiovascular risks, aggressive preventive strategies and regular echocardiographic screening are warranted in this high-risk group.
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Makhdoom et al. (2026) conducted a cross-sectional in End-stage renal disease (n=140). End-stage renal disease on maintenance hemodialysis was evaluated on Prevalence of aortic valve calcification (AVC). Among patients with end-stage renal disease on maintenance hemodialysis, the prevalence of mitral and aortic valve calcification was 30.7% and 31.4% respectively, with significantly higher rates in those aged 40 and older.
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