Life-Threatening Hypertensive Crises in Two Patients Undergoing Hepatic Radiofrequency Ablation

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Hypercortisolism (functional adrenal tumour) and renal cell carcinoma (n=1). Intervention: Intraoperative laparotomic ethanol ablation. Primary outcome: Hypercortisolism control and tumor regression.

Q: What does this research mean for the field?

Hepatic radiofrequency ablation can trigger life-threatening hypertensive crises. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Gary M. Onik; Casey Onik; Irene Medary; Debra M. Berridge; Debra S. Chicks; Lester T. Proctor; Thomas C. Winter; Fred T. Lee

doi:10.2214/ajr.181.2.1810495

August 1, 2003American Journal of Roentgenology

Life-Threatening Hypertensive Crises in Two Patients Undergoing Hepatic Radiofrequency Ablation

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Study Design

Type

Case Report (n=1)

Multicenter

No

PICO

P

Population

One 13-year-old female neutered toy-poodle with hypercortisolism secondary to a left adrenal tumor and concurrent renal cell carcinoma, followed for 753 days.

I

Intervention / Comparator

Intraoperative laparotomic ethanol ablation (4 mL (0.8 mL/kg) absolute ethanol)

O

Primary Outcome

Hypercortisolism control and tumor regression

Limitations

The method of ethanol ablation to the adrenal gland was not optimized.
Blood ethanol concentrations were not measured before and after ethanol ablation, leaving the pharmacokinetics and safe dose of ethanol unknown.
Pituitary involvement was unclear because post-mortem brain tissue was not collected.

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Implication

Single-case canine success; leaves open whether ethanol ablation merits prospective veterinary or human trials.

Abstract

Life-Threatening Hypertensive Crises in Two Patients Undergoing Hepatic Radiofrequency AblationGary Onik1, Casey Onik1, Irene Medary1, Debra M. Berridge2, Debra S. Chicks2, Lester T. Proctor3, Thomas C. Winter, III2 and Fred T. Lee, Jr.2Audio Available | Share

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Cite This Study

Onik et al. (2003) conducted a case report in Hypercortisolism (functional adrenal tumour) and renal cell carcinoma (n=1). Intraoperative laparotomic ethanol ablation was evaluated on Hypercortisolism control and tumor regression.

synapsesocial.com/papers/6ac73f0c3691e9d7c34dabb5 https://doi.org/10.2214/ajr.181.2.1810495

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Life-Threatening Hypertensive Crises in Two Patients Undergoing Hepatic Radiofrequency Ablation

Study Design

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Life-Threatening Hypertensive Crises in Two Patients Undergoing Hepatic Radiofrequency Ablation

Study Design

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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