Key result
Orientin reduced myocardial fibrosis and apoptosis, and improved cardiac function in a mouse model of diabetic cardiomyopathy by modulating the H19/miR-103-3p/ALDH2/PI3K/AKT axis.
Why the study?
Does orientin improve cardiac function and reduce oxidative stress and apoptosis in preclinical models of diabetic cardiomyopathy?
Does orientin improve cardiac function and reduce oxidative stress and apoptosis in preclinical models of diabetic cardiomyopathy?
This editorial highlights preclinical evidence that orientin may alleviate diabetic cardiomyopathy through modulation of the H19/miR-103-3p/ALDH2/PI3K/AKT axis, presenting a potential future therapeutic target.
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Ojopi et al. (2025) conducted an editorial in Diabetic Cardiomyopathy. Orientin vs. Untreated diabetic control was evaluated on Myocardial fibrosis, apoptosis, and cardiac function. Orientin reduced myocardial fibrosis and apoptosis, and improved cardiac function in a mouse model of diabetic cardiomyopathy by modulating the H19/miR-103-3p/ALDH2/PI3K/AKT axis.
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