Why the study?
Persistent or exaggerated aortic flow reversal in pediatrics indicates altered central hemodynamics and provides functional insight beyond anatomical diagnosis, but its clinical translation and Doppler characterization require clarification.
Observational
Effect estimate: 72.72% decrease (95% CI -83.67 to -55.14)
Absolute Event Rate: 72.57% vs 298.93%
Although the burden of neural tube defects in the MENA region decreased significantly from 1990 to 2021, severe disparities remain linked to sociodemographic index, highlighting the need for mandatory folic acid fortification and targeted public health policies in conflict-affected areas.
Normal aortic Doppler flow shows systolic antegrade flow with brief early diastolic reversal due to arterial recoil. Persistent or exaggerated reversal indicates altered central hemodynamics rather than a single disease and may result from regurgitant lesions, systemic–pulmonary runoff, vascular changes, or severe circulatory compromise. Evaluation of timing, duration, and magnitude of reversal provides functional insight into physiological severity and systemic perfusion beyond anatomical diagnosis. Echocardiographic detection – via transthoracic, transesophageal, or cardiac -point of care ultrasound imaging – offers rapid, noninvasive quantification, aiding in the grading of regurgitation, assessing shunt burden, and identifying low-output states. Aortic flow reversal is thus a versatile echocardiographic marker for diagnosis, triage, and prognostication across congenital and systemic circulatory disorders.
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Tomar et al. (2026) conducted an observational in Neural tube defects. Time period (1990 to 2021) vs. 1990 baseline rates was evaluated on Age-standardized DALY rate for NTDs per 100,000 population (72.72% decrease, 95% CI -83.67 to -55.14).
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