Key result
[11C]OHB PET strongly correlates with invasive AV balance for myocardial ketone uptake.
Why the study?
Accurate assessment of myocardial ketone uptake and oxidation is essential for understanding cardiac metabolism, and validation of PET imaging against invasive methods is needed.
Does [11C]OHB PET imaging accurately quantify myocardial ketone uptake and oxidation compared to invasive AV balance methods in healthy pigs?
Does [11C]OHB PET imaging accurately quantify myocardial ketone uptake and oxidation compared to invasive AV balance methods in healthy pigs?
[11C]OHB PET imaging serves as a reliable, non-invasive tool for assessing myocardial ketone metabolism in vivo, strongly correlating with invasive reference methods.
Answers are grounded in this paper and cite their sources.
[11C]OHB PET accurately quantifies myocardial ketone uptake in pigs; leaves open translation to human metabolic research.
Accurate assessment of myocardial ketone uptake and oxidation is essential for understanding cardiac metabolism. This study aims to validate positron emission tomography (PET) imaging as a non-invasive method for quantifying myocardial ketone metabolism, using the invasive arteriovenous (AV) balance method as reference. Myocardial ketone uptake was assessed using [ 11 C]β-hydroxybutyrate ([ 11 C]OHB) PET imaging in a porcine model. Blood samples were collected from arterial and coronary sinus sites, and kinetic parameters were calculated to evaluate the relationship between PET-derived and AV balance-derived measurements. Myocardial perfusion was assessed using [ 15 O]water PET scans. The procedures were conducted during a graded infusion of ketone salt. A strong positive correlation between PET-derived and AV balance-derived measurements of myocardial OHB uptake was observed ( r = 0.97; p < 0.0001), indicating that [ 11 C]OHB PET imaging can reliably assess myocardial ketone metabolism. The correlation between the rate constant k 2 and the [ 11 C]CO 2 fraction in coronary sinus blood was near-significant, moderate and positive ( r = 0.71; p = 0.08), suggesting potential for k 2 as a marker of myocardial ketone oxidation. [ 11 C]OHB PET imaging is a non-invasive tool for assessing myocardial ketone metabolism, providing valuable insights into ketone uptake and oxidation in vivo, with potential for extrapolation to human data.
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Kjærulff et al. (2025) studied Healthy pigs. [11C]β-hydroxybutyrate ([11C]OHB) PET imaging vs. Invasive arteriovenous (AV) balance method was evaluated on Correlation between PET-derived and AV balance-derived measurements of myocardial OHB uptake (r = 0.97, p=< 0.0001). [11C]OHB PET imaging demonstrated a strong positive correlation with the invasive arteriovenous balance method for assessing myocardial ketone uptake in a porcine model (r = 0.97; p < 0.0001).
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