Key result
Electroacupuncture plus aconitine may improve heart failure via SERCA2a upregulation and PLB downregulation.
Why the study?
The mechanisms underlying the synergistic and attenuated effects of aconitine combined with electroacupuncture in heart failure treatment were not well understood.
Hypothesis-generating in rodent heart failure models; prospective human trials needed before clinical consideration.
OBJECTIVE: -ATPase2a (SERCA2a)/phospholamban (PLB) on the synergistic and attenuated effect of aconitine for heart failure. METHODS: ) were detected and arrhythmia types were observed and scored. SERCA2a protein and PLB protein expressions in left ventricular myocardial tissue of rats were detected by multiplex fluorescence Western blot. RESULTS: <0.01). CONCLUSION: The intervention with electroacupuncture achieves the synergism/ attenuation effect of aconitine for the improvements in heart failure probably by up-regulating the expression of SERCA2a and down-regulating the expression of PLB in myocardial tissue.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2021) conducted a review in Heart failure and Aconitine toxicity. Electroacupuncture and Aconitine was evaluated. Electroacupuncture combined with aconitine may improve heart failure by up-regulating SERCA2a and down-regulating PLB expression in myocardial tissue.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: