A near-infrared continuous-wave optical tomographic system for in vivo breast imaging is presented. The system primarily consists of three diode lasers at 785, 808, and 830 nm, 64×64 channel source/detector optic fibers for light delivery/receiving, and 16 computer gain controlled photomultiplier tubes for parallel detection. Central to the system is a fiber optic probe that is composed of four layers of illuminating/receiving fibers arranged in a frustum of cone-shaped configuration. This probe provides data sets for both two-dimensional (2D) and three-dimensional (3D) imaging. The system is computer controlled via Labview software. A full set of tomographic data (64×64) at one wavelength can be obtained in 4 min. All hardware components are contained in a single frame under an exam table which makes the entire hardware a compact and mobile system. The design, calibration, and performance of the imaging system are described in detail. The system is tested using tissue-like phantom experiments. Both 2D and 3D images of optical absorption and reduced scattering coefficients are obtained using powerful finite element based reconstruction algorithms.
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Iftimia et al. (2003) studied this question.
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