Key result
Hypertension was not associated with an increased risk of incident Alzheimer's disease compared to subjects without hypertension.
Why the study?
The association between hypertension or antihypertensive medication use and risk for incident Alzheimer's disease was uncertain.
Meta-Analysis (n=15,292)
Answers are grounded in this paper and cite their sources.
No hypertension-Alzheimer's link in observational meta-analysis; leaves open causal effects and need for randomized trials.
This study examined the association between hypertension and AD by using a quantitative meta-analysis of longitudinal studies. EMBASE and MEDLINE were searched for articles published up to February 2011. All studies that examined the association of hypertension or antihypertensive medication use with the onset of AD were included. Pooled relative risks (RR) were calculated using fixed and random effects models. Twelve studies met our inclusion criteria for this meta-analysis. All subjects were without dementia at baseline. Among them, 9 studies compared the incidence of AD between subjects with (7,270) and without (8,022) hypertension. The quantitative meta-analysis showed that there was no significant difference in incidence of AD (RR: 1.02, 95% confidence interval (CI): 0.91-1.14) between subjects with and without hypertension. Seven studies compared the incidence of AD between subjects with (8,703) and without (13,041) antihypertensive medication use. The quantitative meta-analysis showed that there was no significant difference in incidence of AD (RR: 0.90, 95% CI: 0.79-1.03) between subjects with and without antihypertensive medication use. The quantitative meta-analysis showed that neither hypertension nor antihypertensive medication use was associated with risk for incident AD.
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Guan et al. (2011) conducted a meta-analysis in Alzheimer's Disease (n=15,292). Hypertension vs. Without hypertension was evaluated on Incidence of Alzheimer's disease (RR 1.02, 95% CI 0.91-1.14). Hypertension was not associated with an increased risk of incident Alzheimer's disease compared to subjects without hypertension.
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