Key result
Cardiopulmonary bypass over 120 minutes is linked to ~86% higher odds of 30-day gastrointestinal complications.
Why the study?
Factors influencing mortality in patients developing gastrointestinal complications after cardiac surgery were not well defined.
Cohort (n=1,444)
No
Odds Ratio: 1.86 (95% CI 1.06–3.26)
Absolute Event Rate: 8.09% vs 4.31%
p-value: p=0.029
May warrant heightened GI monitoring after long bypass; leaves open causal confirmation and practice change in modern cohorts.
This study sought to determine which factors influence the mortality rate in patients developing gastrointestinal complications following cardiac surgery. Between July 1988 and January 1992, 2054 patients underwent cardiac surgical procedures at the Boston University Medical Center. Of these, 29 (1.4%) developed postoperative gastrointestinal complications. The overall mortality rate among these patients was 27% (8/29). Those who died following such complications had a higher incidence of New York Heart Association (NYHA) class IV and unstable symptoms (8/8, 100% versus 3/21, 14%; P < 0.0001), and an increased need for preoperative intra-aortic balloon pump support (4/8, 50% versus 1/21, 5%; P < 0.004). The need for gastrointestinal surgical intervention increased the mortality rate significantly compared with patients managed medically (8/18, 44% versus 0/11, 0%; P < 0.01). Patients with ischemic bowel also had a significantly higher mortality (5/5, 100% versus 3/24, 12%; P < 0.001). It is concluded that most patients with gastrointestinal complications following cardiac surgery can be treated, and with acceptable mortality rates. The presence of unstable symptoms, preoperative intra-aortic balloon pump support, ischemic bowel and the need for gastrointestinal surgical intervention adversely affect mortality.
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Harold L. Lazar (1995) conducted a cohort in Cardiovascular diseases requiring cardiac surgery with cardiopulmonary bypass (n=1,444). Prolonged cardiopulmonary bypass (≥120 min) vs. Normal cardiopulmonary bypass (<120 min) was evaluated on Occurrence of gastrointestinal complications within 30 days post-surgery (OR 1.86, 95% CI 1.06-3.26, p=0.029). Prolonged cardiopulmonary bypass duration of 120 minutes or more was independently associated with a significantly higher risk of 30-day postoperative gastrointestinal complications (OR 1.86).
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