Key result
Modified fasting therapy linked to ~8 mmHg lower systolic blood pressure in dysglycemic adults.
Why the study?
The effect of modified fasting therapy on blood pressure in dysglycemic adults and the mediating role of weight loss with modifying effects of age, sex, and baseline glycemic status were unclear.
Does modified fasting therapy reduce blood pressure in dysglycemic adults?
Cohort (n=833)
No
Does modified fasting therapy reduce blood pressure in dysglycemic adults?
Mean Difference: -7.73 (95% CI -8.64–-6.82)
p-value: p=<0.001
Modified fasting therapy rapidly lowers blood pressure in dysglycemic adults through mechanisms independent of weight loss, with greater efficacy in younger men with higher baseline HbA1c.
Modified fasting may lower SBP independent of weight loss in dysglycemia; hypothesis-generating and requires randomized confirmation before practice change.
Objective To evaluate the effect of modified fasting therapy on blood pressure in dysglycemic adults and to examine the mediating role of weight loss and modifying effects of age, sex, and baseline glycemic status. Methods This retrospective cohort study included 833 dysglycemic adults who underwent modified fasting therapy. Blood pressure, body weight, and laboratory parameters were measured before and after the intervention. Linear mixed models were used to estimate the effect of fasting on systolic blood pressure (SBP) and diastolic blood pressure (DBP), with adjustment for age, sex, baseline body mass index (BMI), glycosylated hemoglobin (HbA1c), and baseline blood pressure. Mediation analyses were performed using “MEMORE macro” and “wsMed” package to examine the mediating role of weight loss. Interaction terms were included to test effect modification by age, sex, and baseline HbA1c. Results Fasting therapy significantly reduced SBP (−7.73 mmHg, 95% CI: −8.64 to −6.82, p < 0.001) and DBP (−4.76 mmHg, 95% CI: −5.39 to −4.12, p < 0.001). Mediation analyses revealed that weight loss did not significantly mediate the blood pressure-lowering effect for either SBP (indirect effect: −0.22, p = 0.588) or DBP (indirect effect: 0.09, p = 0.636). The fasting effect was significantly modified by age, sex, and baseline HbA1c, with greater reductions observed in younger patients, males, and those with higher HbA1c levels. Conclusions Modified fasting therapy significantly reduces blood pressure in dysglycemic adults independent of weight loss. Age, sex, and baseline HbA1c modify the response, suggesting that personalized approaches may optimize the benefits of fasting-based interventions.
No takes yet. Share an insight, caveat, or question.
Ye et al. (2026) conducted a cohort in Dysglycemia (n=833). Modified fasting therapy vs. Pre-fasting baseline was evaluated on Change in systolic blood pressure (SBP) (MD -7.73, 95% CI -8.64 to -6.82, p=<0.001). Modified fasting therapy significantly reduced systolic blood pressure by 7.73 mmHg from baseline in dysglycemic adults, an effect that was largely independent of weight loss.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: