Key result
An immunoenzymometric assay for creatine kinase-MB demonstrates different mass and catalytic activity correlations in patients with myocardial infarction compared to those with skeletal muscle damage.
Why the study?
The study aimed to validate an immunoenzymometric assay for specific measurement of CK-MB isoenzyme and its diagnostic application in myocardial infarction.
Key points are not available for this paper at this time.
Comparison
Patients with myocardial infarction vs patients with skeletal muscle damage
Design
Analytical validation of an immunoenzymometric assay
May warrant caution interpreting CK-MB mass-activity correlations in MI; leaves open assay standardization across injury types.
The analytical validation of an immunoenzymometric technique for the specific measurement of the creatine kinase-MB isoenzyme is described. Its application is shown in the diagnosis of myocardial infarction. A difference in the correlation of the mass and catalytic activity of the CK-MB isoenzyme is shown between patients suffering myocardial infarction and those with skeletal muscle damage.
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Youens et al. (1986) studied this question. An immunoenzymometric assay for creatine kinase-MB demonstrates different mass and catalytic activity correlations in patients with myocardial infarction compared to those with skeletal muscle damage.
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