Key result
Familial aggregation of systolic blood pressure is detectable starting at 1 month of age.
Why the study?
Sibling aggregation of blood pressure has been shown in children aged 2 to 14 years, but the earliest age at which this familial influence is detectable was unclear.
Cross-Sectional (n=141)
Effect estimate: ICC 0.21 (95% CI 0.02-0.38)
p-value: p=<0.01
Sibling systolic BP aggregation evident at birth; leaves open early familial influences on hypertension risk and requires prospective validation.
Sibling aggregation of blood pressure has been shown in children 2 to 14 years of age. To determine the earliest age at which this finding is detectable, blood pressures were evaluated in 98 siblings from 43 black families with newborns. Variances of blood pressure scores were significantly greater among families than within families for systolic (p less than .025) but not diastolic pressures. Sib-sib intraclass correlation coefficients were .26 (95% two-sided confidence limits .05 to .47) for systolic and .16 (-.06 to .38) for diastolic pressures. When 1-month-old infant pressures were added, significant aggregation was present for systolic (p less than .01) and diastolic (p less than .025) pressures. The intraclass correlation coefficients were .21 (.02 to .38) and .17 (.03 to .34), respectively. When newborn scores were substituted, aggregation was not demonstrable. These data demonstrate a familial influence on blood pressure in infancy by 1 month of age.
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Hennekens et al. (1976) conducted a cross-sectional in Blood pressure aggregation (n=141). Familial relationship (sibling aggregation) was evaluated on Sibling aggregation of systolic and diastolic blood pressures (intraclass correlation coefficients) (ICC 0.21, 95% CI 0.02-0.38, p=<0.01). Familial aggregation of systolic blood pressure was detectable when including 1-month-old infants, with an intraclass correlation coefficient of 0.21 (95% CI 0.02-0.38; p<0.01).
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