Key result
Warfarin prevents blood clots by inhibiting vitamin K-dependent clotting factors.
Why the study?
Warfarin is widely used to prevent harmful blood clots, but patient guidance on its mechanism and use is needed.
Answers are grounded in this paper and cite their sources.
Warfarin requires vigilant INR monitoring in practice; Level 5 data leaves optimal strategies in subgroups open.
W arfarin (brand names Coumadin and Jantoven) is a prescription medication used to prevent harmful blood clots from forming or growing larger.Beneficial blood clots prevent or stop bleeding, but harmful blood clots can cause a stroke, heart attack, deep vein thrombosis, or pulmonary embolism.Because warfarin interferes with the formation of blood clots, it is called an anticoagulant.Many people refer to anticoagulants as "blood thinners"; however, warfarin does not thin the blood but instead causes the blood to take longer to form a clot. How Does Warfarin Work?The formation of a clot in the body is a complex process that involves multiple substances called clotting factors.Warfarin decreases the body's ability to form blood clots by blocking the formation of vitamin K-dependent clotting factors.Vitamin K is needed to make clotting factors and prevent bleeding.Therefore, by giving a medication that blocks the clotting factors, your body can stop harmful clots from forming and prevent clots from getting larger.The information contained in this Circulation Cardiology Patient Page is not a substitute for medical advice, and the American Heart Association recommends consultation with your doctor or healthcare professional.
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Fiumara et al. (2009) studied this question. Warfarin was evaluated. Warfarin is an anticoagulant that prevents harmful blood clots from forming by blocking vitamin K-dependent clotting factors.
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