Why the study?
Many individuals consume daily aspirin for cardiovascular risk prevention without adequate understanding of its risk-benefit profile despite longstanding guideline recommendations.
May support anti-inflammatory effects of willow extracts; leaves open any shift from aspirin in cardiovascular prevention.
Aspirin, or acetylsalicylic acid, is derived from a substance that accumulates in willow trees. Extracts from the bark and leaves contain salicylic acid, used since the time of the Egyptians for the relief of pain. Over the years, the expression, “an aspirin a day keeps the doctor away” has become embedded in our collective psyche, leading to countless individuals consuming this over‐the‐counter preparation on a daily basis without an adequate understanding of its risk‐benefit profile. The public has received the message for decades from numerous guidelines and the manufacturers of aspirin that aspirin should be taken by all adults at risk for cardiovascular disease events.
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Krantz et al. (2010) studied In vitro inflammation. Salix pentandra methanol extract and isolated compounds vs. Solvent control and acetylsalicylic acid (ASA) was evaluated on Inhibition of prostaglandin E2 (PGE2) release in LPS-stimulated human PBMCs (p=<0.05).
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