Key result
Intraoperative TEE enables real-time detection and prompt management of intracardiac thrombus during liver transplantation.
Why the study?
Intracardiac thrombi formation during orthotopic liver transplant is rare, poorly understood, and lacks consensus on optimal treatment strategies.
Case Report (n=1)
May support TEE for real-time thrombus management in liver transplant; hypothesis-generating and leaves open routine adoption.
The exact origin of intracardiac thrombi formation during orthotopic liver transplant remains unknown. The altered balance between hypercoagulability, hypocoagulation, and endothelial dysfunction associated with end-stage liver disease is thought to play a pivotal role. Venous stasis, vascular clamping, and reperfusion could also contribute to clot formation. The incidence of intracardiac thrombi formation stands at 4.2%, associated with a mortality rate of 45.5%, and to date, no consensus exists regarding the best way to treat this complication. Intraoperative transesophageal echocardiography is the only effective method for diagnosing intracardiac thrombi formation early, while point-of-care coagulation testing could guide the coagulation management potentially improving patient outcomes.
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Vetrugno et al. (2021) conducted a case report in Intracardiac thrombus during orthotopic liver transplantation (n=1). Transesophageal echocardiography (TEE) and point-of-care coagulation testing was evaluated. Transesophageal echocardiography allowed for the real-time diagnosis of a rare intracardiac thrombus during orthotopic liver transplantation, facilitating immediate pharmacological management.
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