Key result
Chronic liver disease is linked to ~3-fold higher prevalence of LV diastolic dysfunction.
Why the study?
Cirrhotic cardiomyopathy encompasses cardiovascular abnormalities including diastolic and systolic dysfunctions in chronic liver disease patients, contributing to morbidity and mortality.
Cross-Sectional (n=160)
No
Absolute Event Rate: 40% vs 13.8%
p-value: p=<0.001
Diastolic dysfunction may be more common in chronic liver disease; extends cirrhotic cardiomyopathy observations but remains hypothesis-generating and should not change practice.
Objectives: The term cirrhotic cardiomyopathy (CCM) has been used to describe the constellation of cardiovascular abnormalities including diastolic and systolic dysfunctions in patients with chronic liver disease (CLD). CCM contributes to morbidity and mortality associated with CLD. The aim of the study was to evaluate the left atrial and ventricular geometry, systolic and diastolic functions in patients with CLD. Material and Methods: This was a cross-sectional analytical study that involved 80 patients with CLD seen at University of Calabar Teaching Hospital, Calabar, Nigeria, and 80 apparently healthy controls matched for age/ gender. The participants were interviewed, examined and had resting transthoracic echocardiography. The data were analyzed using IBM SPSS version 20.0. Results: A total of 160 subjects were recruited into the study with a male to female ratio of 2.8:1. There was no difference in the mean age of cases and controls (P = 0.115). Systolic function of the left ventricle was similar in the two arms. However, left ventricular diastolic dysfunction, left atrial enlargement, and increased left ventricular mass index (LVMI) were more prevalent among the patients with CLD compared to controls (P < 0.05). Conclusion: The study demonstrated increased left atrial diameter, increased LVMI associated with diastolic dysfunction, and preserved systolic function at rest among CLD patients.
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Njideofor et al. (2021) conducted a cross-sectional in Chronic Liver Disease (n=160). Chronic liver disease vs. Healthy controls matched for age and gender was evaluated on Prevalence of left ventricular diastolic dysfunction (p=<0.001). Patients with chronic liver disease had a significantly higher prevalence of left ventricular diastolic dysfunction compared to healthy controls (40.0% vs. 13.8%, p < 0.001), while systolic function was preserved.
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