Immunological Responsiveness of the Aged in the North

The comparative analysis of immunological responsiveness in the elderly and old people and middle-aged persons, born and lived in the north has been carried out. Analyzing levels of various clinical manifestations of immune protection insufficiency depending on the age, one can say that the frequency of registration of chronic inflammatory processes, and also diseases in which pathogenesis hypersensitivity of delayed type and high level autoimmune reactions lie increase with age. It has been revealed that densification of mucin glycoproteins in blood with age increase was connected with necessity of more effective protection of the surface epithelium of the mucous by epitheliocytes activation, nonspecific barrier function and local immunity reactions. The content and the structure of cell-associated mucous tissue are refilled by migration of neutrophils, mid cells / macrophages, natural killer cells. One gets the impression that the levels of phagocytic activity, especially neutrophils depend on microorganisms concentration in the barrier organs and are regulated by functional state of the cells in paracrine community. In cases when response of innate immunity cannot cope with the influence of pathogenic microflora, this community of paracrine cells initiates the development of specific reactions of adaptive immunity. Content increasing of cytokines, cytotoxic lymphocytes, lymphoproliferation are a reflection of those reactions, which are aimed at preservation of homeostasis in conditions of decrease or loss of threshold standards, or resistance increase to the inhibitory effect of homeostatic stimuli.